In digital pathology, it is often useful to align spatially close but differently stained tissue sections in order to obtain the combined information. The images are large, in general, their appearance and their local structure are different, and they are related through a nonlinear transformation. The proposed challenge focuses on comparing the accuracy and approximative speed of automatic non-linear registration methods for this task. Registration accuracy will be evaluated using manually annotated landmarks. All methods are supposed to run fully automatically, with no image specific parameters.