The Markov random field (MRF) is one of the most widely used models in image processing, constituting a prior model for addressing problems such as image segmentation, object detection, and reconstruction. What is not often appreciated is that the MRF owes its origin to the physics of solids, making it an ideal prior model for processing microscopic observations of materials. While both fields know of their respective interpretations of the MRF, each knows very little about the other’s version of it. Hence, both fields have “blind spots,” where some concepts readily appreciated by one field are completely obscured from the other.