Ice-Tide: Implicit Cryo-ET Imaging and Deformation Estimation
We introduce ICE-TIDE, a method for cryogenic electron tomography (cryo-ET) that simultaneously aligns observations and reconstructs a high-resolution volume. The alignment of tilt series in cryo-ET is a major problem limiting the resolution of reconstructions. ICE-TIDE relies on an efficient coordinate-based implicit neural representation of the volume which enables it to directly parameterize deformations and align the projections.