The PALM challenge focuses on investigation and development of algorithms associated with diagnosis of Pathologic Myopia (PM) and segmentation of lesions in fundus photos from PM patients. Myopia is currently the ocular disease with the highest morbidity. About 2 billion people have myopia in the world, 35% of which are high myopia. High myopia leads to elongation of axial length and thinning of retinal structures. With progression of the disease into PM, macular retinoschisis, retinal atrophy and even retinal detachment may occur, causing irreversible impairment to visual acuity.