Digital pathology has been gradually introduced in clinical practice. Although the digital pathology scanner could give very high resolution whole-slide images (WSI) (up to 160nm per pixel), the manual analysis of WSI is still a time-consuming task for the pathologists. Automatic analysis algorithms offer a way to reduce the burden for pathologists. Our proposed challenge will focus on automatic detection and classification of lung cancer using Whole-slide Histopathology. This subject is highly clinical relevant because lung cancer is the top cause of cancer-related death in the world.