This Funding Opportunity Announcement (FOA) seeks applications that propose research studies that extend experimental protocols beyond the range of acoustic psychophysical research studies widely performed today. This will require design of algorithms and research studies that validate the potential benefits from these novel approaches to acoustic signal processing. Studies that employ substantial computing power are encouraged in order to provide publications in the peer-reviewed literature that will inform efforts to develop real-time speech enhancement technologies for use in hearing aids, cochlear implants, personal sound processors, and consumer electronic devices. Participating Organization: National Institutes of Health (NIH) Component of Participating Organization: National Institute on Deafness and Other Communication Disorders (NIDCD) For more details, please visit: http://grants.nih.gov/grants/guide/rfa-files/RFA-DC-16-001.html