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The imaging of the dynamics of single molecules in live cells has the promise of revolutionizing cell biology and has attracted very significant attention cell biology, biophysics and physical chemistry.
These techniques bring about unique challenges regarding the analysis of the acquired images since the signal from the single molecules is typically very weak in the presence of significant sources of noise. At the same time the biological requirements demand that distances between proteins are measured well below the classical resolution limits. A major aspect of our research program has been the development of signal and image processing approaches to address these exciting problems. The NIH supported projects aim to develop parameter estimation approaches and novel tracking methodologies for the particular problems.
The positions will provide the opportunity to not only work on projects of significant technical interest but also to become familiar with the fundamental biological questions that are being addressed in the laboratory. Specifically the laboratory investigates the trafficking of therapeutically relevant engineered antibodies in live cell environment, a problem that is major interest in the biopharma industry.
For more information on the research carried out in the laboratory see www.wardoberlab.com. Highly motivated individuals with a background in signal processing, statistics, applied mathematics or equivalent qualification will be considered. Direct experience is not necessary. These positions provide the opportunity for the successful candidate to gain expertise in advanced microscopic techniques applied to important problems in biotechnology.
Please send inquiries (resume, names of referees etc.) to
Prof. Raimund J. Ober
Departments of Electrical Engineering and Bioengineering
University of Texas at Dallas
email: positioninfo@wardoberlab.com
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