The American Epilepsy Society Seizure Prediction Challenge, hosted on Kaggle.com, started on 25 August 2014, and will end on 17 November 2014. It is the second phase of the Seizure Detection and Prediction Challenge designed by researchers from the University of Pennsylvania and the Mayo Clinic. The first phase (ended on August 19, 2014), focusing on seizure detection, has attracted 200 teams, 241 players, and 4503 entries. Sponsored by the National Institutes of Health (NINDS), the Epilepsy Foundation, and the American Epilepsy Society, the Seizure Prediction Challenge aims to demonstrate the existence and accurate classification of the preictal brain state in dogs and humans with naturally occurring epilepsy. Participants are encouraged to use additional annotated interictal and preictal data from other patients and animal subjects by visiting the International Epilepsy Electrophysiology Portal. A total of $25,000 in prizes will be rewarded to the top 3 teams by the end of the competition. For more details and to participate in the challenge, please visit https://www.kaggle.com/c/seizure-prediction.