SPS BSI Webinar: Functional PET-MRI of brain network dynamics across tasks and arousal states

Date: 28 March 2025
Time: 1:00 PM ET (New York Time)
Presenter(s): Dr. Jingyuan E. Chen

Meeting information:
Meeting number: 2861 854 2865
Password: UmSZpAtt553 (86797288 when dialing from a phone or video system)

Join by phone:
+1-415-655-0002 US Toll
Access code: 2861 854 2865

Join us Friday, 28 March 2025, at 1:00 PM ET for an exciting virtual talk by Dr. Jingyuan E. Chen entitled: “Functional PET-MRI of brain network dynamics across tasks and arousal states”” as part of the activities of the Brain Space Initiative, co-sponsored by the Center for Translational Research in Neuroimaging and Data Science (TReNDS) and the Data Science Initiative, IEEE Signal Processing Society.

Abstract

Recently, the field of neuroimaging has seen a resurgence of interest in functional positron emission tomography (fPET)-FDG (2-[18F]-fluorodeoxyglucose) imaging, the dominant technique for non-invasive human brain mapping before the advent of functional magnetic resonance imaging (fMRI). This renewed attention in fPET-FDG is driven by refinements in tracer administration for dynamic metabolic imaging and its potential to address key limitations of existing neuroimaging techniques. In this talk, I will first introduce the fPET-FDG technique, highlighting its temporal characteristics with empirical sensory task data. I will then present our research integrating fPET-FDG with simultaneous (EEG-)fMRI to elucidate the metabolic states underlying large-scale brain functional dynamics across various tasks and sleep. Finally, I will discuss our ongoing efforts to enhance the statistical parametric mapping for fPET-FDG.

Biography

Dr. Chen

Dr. Chen is an Assistant Professor at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital and Harvard Medical School. She earned her Ph.D. from Stanford University, with a major in Electrical Engineering and a minor in Statistics. Following graduation, she pursued further training in neuroimaging as a postdoctoral fellow at the Martinos Center. Her lab advances neuroimaging techniques (with a focus on functional PET-MRI and ultra-high-field fMRI) and computational approaches to investigate the biophysical and molecular mechanisms underlying intrinsic brain activity and the neurobiological consequences of cognition, arousal, and disease.

 

Recommended Articles:

  • Villien, M., Wey, H. Y., Mandeville, J. B., Catana, C., Polimeni, J. R., Sander, C. Y., ... & Hooker, J. M. (2014). Dynamic functional imaging of brain glucose utilization using fPET-FDG. Neuroimage, 100, 192-199. (Link to Paper).
  • Chen, J. E., Lewis, L., Coursey, S., Catana, C., Polimeni, J., Fan, J., ... & Rosen, B. R. (2025). Simultaneous EEG-PET-MRI identifies temporally coupled, spatially structured hemodynamic and metabolic dynamics across wakefulness and NREM sleep. bioRxiv, 2025-01. (Link to Paper).
  • Coursey, S. E., Mandeville, J., Reed, M. B., Hartung, G. A., Garimella, A., Sari, H., ... & Chen, J. E. (2024). On the analysis of functional PET (fPET)-FDG: baseline mischaracterization can introduce artifactual metabolic (de) activations. bioRxiv. (Link to Paper).

 

Dr. Chen