SPS BSI Webinar: Functional PET-MRI of brain network dynamics across tasks and arousal states

Date: 28 March 2025
Time: 1:00 PM ET (New York Time)
Presenter(s): Dr. Jingyuan E. Chen

Meeting information:
Meeting number: 2861 854 2865
Password: UmSZpAtt553 (86797288 when dialing from a phone or video system)

Join by phone:
+1-415-655-0002 US Toll
Access code: 2861 854 2865

Join us Friday, 28 March 2025, at 1:00 PM ET for an exciting virtual talk by Dr. Jingyuan E. Chen entitled: “Functional PET-MRI of brain network dynamics across tasks and arousal states”” as part of the activities of the Brain Space Initiative, co-sponsored by the Center for Translational Research in Neuroimaging and Data Science (TReNDS) and the Data Science Initiative, IEEE Signal Processing Society.

Abstract

Recently, the field of neuroimaging has seen a resurgence of interest in functional positron emission tomography (fPET)-FDG (2-[18F]-fluorodeoxyglucose) imaging, the dominant technique for non-invasive human brain mapping before the advent of functional magnetic resonance imaging (fMRI). This renewed attention in fPET-FDG is driven by refinements in tracer administration for dynamic metabolic imaging and its potential to address key limitations of existing neuroimaging techniques. In this talk, I will first introduce the fPET-FDG technique, highlighting its temporal characteristics with empirical sensory task data. I will then present our research integrating fPET-FDG with simultaneous (EEG-)fMRI to elucidate the metabolic states underlying large-scale brain functional dynamics across various tasks and sleep. Finally, I will discuss our ongoing efforts to enhance the statistical parametric mapping for fPET-FDG.

Biography

Dr. Chen is an Assistant Professor at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital and Harvard Medical School. She earned her Ph.D. from Stanford University, with a major in Electrical Engineering and a minor in Statistics. Following graduation, she pursued further training in neuroimaging as a postdoctoral fellow at the Martinos Center. Her lab advances neuroimaging techniques (with a focus on functional PET-MRI and ultra-high-field fMRI) and computational approaches to investigate the biophysical and molecular mechanisms underlying intrinsic brain activity and the neurobiological consequences of cognition, arousal, and disease.

Recommended Articles:

• Villien, M., Wey, H. Y., Mandeville, J. B., Catana, C., Polimeni, J. R., Sander, C. Y., ... & Hooker, J. M. (2014). Dynamic functional imaging of brain glucose utilization using fPET-FDG. Neuroimage, 100, 192-199. (Link to Paper).
• Chen, J. E., Lewis, L., Coursey, S., Catana, C., Polimeni, J., Fan, J., ... & Rosen, B. R. (2025). Simultaneous EEG-PET-MRI identifies temporally coupled, spatially structured hemodynamic and metabolic dynamics across wakefulness and NREM sleep. bioRxiv, 2025-01. (Link to Paper).
• Coursey, S. E., Mandeville, J., Reed, M. B., Hartung, G. A., Garimella, A., Sari, H., ... & Chen, J. E. (2024). On the analysis of functional PET (fPET)-FDG: baseline mischaracterization can introduce artifactual metabolic (de) activations. bioRxiv. (Link to Paper).