SPS BSI Webinar: MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in brain morphology
Date: 31 May 2024
Time: 1:00 PM ET (New York Time)
Presenter(s): Dr. Elisabetta C. del Re
Meeting information:
Meeting number: 2632 269 5821
Password: hPFwSbt7H36 (47397287 when dialing from a phone or video system)
Join by phone:
+1-415-655-0002 US Toll
Access code: 263 226 95821
Join us Friday, May 31st, 2024, at 1:00 PM ET for an exciting virtual talk by Dr. Elisabetta C. del Re entitled: “MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in brain morphology” as part of the activities of the Brain Space Initiative, co-sponsored by the Center for Translational Research in Neuroimaging and Data Science (TReNDS) and the Data Science Initiative, IEEE Signal Processing Society.
Abstract
MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in brain morphology Background/Objective. Enlarged lateral ventricle (LV) volume and decreased volume in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV and CC volumes in SZ, with global functioning decreasing with increased LV volume. This study investigates the relationship between LV volume, CC abnormalities, and the microRNA MIR137 and its regulated genes in SZ, because of MIR137’s essential role in neurodevelopment.
Results: Increased LV volumes and decreased CC central, mid-anterior, and mid-posterior volumes were observed in SZ probands. The MIR137-regulated ephrin pathway was significantly associated with CC:LV ratio, explaining a significant proportion (3.42 %) of CC:LV variance, and more than for LV and CC separately. Other pathways explained variance in either CC or LV, but not both. CC:LV ratio was also positively correlated with Global Assessment of Functioning, supporting previous subsample findings. SNP-based heritability estimates were higher for CC central:LV ratio (0.79) compared to CC or LV separately.
Discussion: Our results indicate that the CC:LV ratio is highly heritable, influenced in part by variation in the MIR137-regulated ephrin pathway. Findings suggest that.
Biography
Elisabetta del Re is an Assistant Professor of Psychiatry at Harvard Medical School and Principal Investigator of NIMH funded research. She has multidisciplinary training in basic science, mental health, neuroimaging, including electrophysiology, and genetics. She holds a MA and PhD in Biochemistry and Experimental Pathology from Boston University; A MA in Mental Health from BGSP. Dr. del Re’s interest is in understanding psychosis and other serious mental illnesses, by looking at the genetics informing neural processes.
Recommended Articles:
- Blokland, Gabriëlla Antonina Maria, et al. "MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume." International Journal of Clinical and Health Psychology 24.2 (2024): 100458. (Link to Paper)
- Heller, Carina, et al. "Smaller subcortical volumes and enlarged lateral ventricles are associated with higher global functioning in young adults with 22q11. 2 deletion syndrome with prodromal symptoms of schizophrenia." Psychiatry Research 301 (2021): 113979. (Link to Paper)
