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A postdoctoral position is available in the Analytical Genomic Team at the Laboratory Genomics of Microorganisms, UMR 7238 CNRS-Université Pierre et Marie Curie.
The postdoctoral researcher will participate to the MAPPING (Making Accurate Predictions of Protein-Protein Interactions on the Genomic scale) project, funded by the french Ministry of Research in the framework of the Programs of Excellence in Bioinformatics. She/he will be responsible for the design and the implementation of sequence analysis methods based on residue coevolution and conservation for the prediction of protein partners and for the refinement of a protein interaction index designed for discriminating true protein partners. The project provides the opportunity for the candidate to develop novel approaches to coevolution analysis aimed at the identification of amino acids networks across protein pairs.
Within the MAPPING consortium, the candidate will interact with theoretical biochemists using molecular simulations coupled with free energy calculations to obtain an atomic-scale view of the dissociation of weak and strong protein interactions, and experimental biochemists using surface plasmon resonance and isothermal titration calorimetry to characterize the thermodynamics of protein interactions over a wide range of affinities and physical conditions.
Postdoctoral support is for 2.5 years. It can start on February 1st, 2014.
Profile of the candidate : The candidate should have a background in computer science, mathematics, physics or bioinformatics (with a solid base in mathematics and computer science). Doctoral or postdoctoral experience in protein sequence/structure or/and sequence evolution is desirable. He/she should also have strong computing skills.
Contact: All interested candidate should contact Alessandra Carbone (Alessandra.Carbone@lip6.fr) and send a cv with two reference names.
About the university and the lab: The University Pierre et Marie Curie in Paris is one of the largest (30,000 students, 3,250 researchers) in France and it features a dynamic and valuable work site in the heart of Paris. The candidate will join the Analytical Genomics team headed by A.Carbone at the laboratory Genomics of Microorganisms (http://www.lgm.upmc.fr/). The laboratory provides a fully interdisciplinary environment by regrouping experimental biologists and physicists, mathematicians and computer scientists interested in genomics, evolution and environmental adaptation. Information on the team can be found athttp://www.lgm.upmc.fr/AnalyticalGenomics.
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