Chen, Jeane, (Northwestern University) “Poly(lactide-co-glycolide) Microspheres for Localized, Magnetic Resonance Imaging Monitored, Transcatheter Delivery of Sorafenib to Hepatocellular Carcinoma” (2015)

You are here

Inside Signal Processing Newsletter Home Page

Top Reasons to Join SPS Today!

1. IEEE Signal Processing Magazine
2. Signal Processing Digital Library*
3. Inside Signal Processing Newsletter
4. SPS Resource Center
5. Career advancement & recognition
6. Discounts on conferences and publications
7. Professional networking
8. Communities for students, young professionals, and women
9. Volunteer opportunities
10. Coming soon! PDH/CEU credits
Click here to learn more.

10 years of news and resources for members of the IEEE Signal Processing Society

Chen, Jeane, (Northwestern University) “Poly(lactide-co-glycolide) Microspheres for Localized, Magnetic Resonance Imaging Monitored, Transcatheter Delivery of Sorafenib to Hepatocellular Carcinoma” (2015)

Chen, Jeane, (Northwestern University) “Poly(lactide-co-glycolide) Microspheres for Localized, Magnetic Resonance Imaging Monitored, Transcatheter Delivery of Sorafenib to Hepatocellular Carcinoma”, Advisor: Larson, Andrew C., Shea, Lonnie D

Hepatocellular carcinoma is the most common primary liver cancer and is the sixth most common cancer worldwide. Sorafenib has been proven efficacious against hepatocellular carcinoma (HCC) and is the standard of care for patients with advanced stage disease. However, oral systemic administration of sorafenib is associated with severe toxicities (hand foot syndrome, hypertension and gastrointestinal symptoms) and also reduces the dose of sorafenib that reaches the tumors. Typically, systemic administration of chemotherapeutics for HCC has been avoided through a procedure called transarterial chemoembolization (TACE), where a catheter is placed in tumor feeding arteries and a mixture of chemotherapeutics and embolic agents are delivered locally to the tumor. This works to contain the therapy locally at the tumor and to embolize the tumor feeding vessels to starve the tumor. Thus, in this thesis, the author investigates the ability to re-formulate sorafenib as part of an embolic poly(lactide- co -glycolide) microsphere to enable local delivery of sorafenib as part of a TACE procedure. Additionally, the author has incorporated iron oxide nanoparticles to enable MRI visualization of the microspheres for MRI monitoring of the delivery.

Table of Contents:

Research Opportunities

SPS on Twitter

  • Students, it's time to form your teams! The 2022 Signal Processing Cup competition is underway. This year's topic,… https://t.co/fVw7tA7zTG
  • The DEGAS Webinar Series continues this Thursday, 13 January when Peter Battaglia presents "Modeling Physical Struc… https://t.co/Kndvzl8BpE
  • The SPS Webinar Series continues on Wednesday, 26 January when Dr. Ba-Ngu Vo presents "Bayesian Multi-object Tracki… https://t.co/sKejcUeyys
  • Call for Speakers! The IEEE Women in Engineering International Leadership Conference () is seeking submissio… https://t.co/bSaRgMw2uD
  • CALL FOR PROPOSALS: The SPS Education Board is soliciting proposals for short courses in conjunction with ICASSP 20… https://t.co/LiVjYgEVGU

SPS Videos


Signal Processing in Home Assistants

 


Multimedia Forensics


Careers in Signal Processing             

 


Under the Radar